The monthly TRFT Medicines Management Bulletin brings together the latest pharmacological research, organised by BNF category. Contact us to subscribe and receive each issue by email.
November 2015
December 2015
January 2016
November 2015
December 2015
January 2016
Cardiovascular system
Central nervous system
Infections
Obstetrics, gynaecology, and urinary-tract disorders
Malignant disease and immunosuppression
Nutrition and blood
Musculoskeletal and joint diseases
Skin
Children
- Ranolazine in patients with incomplete revascularisation after percutaneous coronary intervention (RIVER-PCI): a multicentre, randomised, double-blind, placebo-controlled trial
- Safety and performance of the second-generation drug-eluting absorbable metal scaffold in patients with de-novo coronary artery lesions (BIOSOLVE-II): 6 month results of a prospective, multicentre, non-randomised, first-in-man trial
- Availability and affordability of cardiovascular disease medicines and their effect on use in high-income, middle-income, and low-income countries: an analysis of the PURE study data
- Selexipag for the Treatment of Pulmonary Arterial Hypertension
Central nervous system
Infections
- Effect of Artesunate–Amodiaquine on Mortality Related to Ebola Virus Disease
- Pre-exposure prophylaxis to prevent the acquisition of HIV-1 infection (PROUD): effectiveness results from the pilot phase of a pragmatic open-label randomised trial
- Azithromycin versus Doxycycline for Urogenital Chlamydia trachomatis Infection
- Sofosbuvir and Velpatasvir for HCV Genotype 1, 2, 4, 5, and 6 Infection
- Sofosbuvir and Velpatasvir for HCV Genotype 2 and 3 Infection
- Sofosbuvir and Velpatasvir for HCV in Patients with Decompensated Cirrhosis
- Intermittent screening and treatment or intermittent preventive treatment with dihydroartemisinin–piperaquine versus intermittent preventive treatment with sulfadoxine–pyrimethamine for the control of malaria during pregnancy in western Kenya: an open-label, three-group, randomised controlled superiority trial
Obstetrics, gynaecology, and urinary-tract disorders
- Maternal use of oral contraceptives and risk of birth defects in Denmark: Prospective, nationwide cohort study
- Ibuprofen versus fosfomycin for uncomplicated urinary tract infection in women: Randomised controlled trial
- Association Between Use of Oral Fluconazole During Pregnancy and Risk of Spontaneous Abortion and Stillbirth
Malignant disease and immunosuppression
- Antilymphocyte Globulin for Prevention of Chronic Graft-versus-Host Disease
- Resensitization to Crizotinib by the Lorlatinib ALK Resistance Mutation L1198F
- Second Cancer Risk Up to 40 Years after Treatment for Hodgkin’s Lymphoma
- Ovarian Suppression With Triptorelin During Adjuvant Breast Cancer Chemotherapy and Long-term Ovarian Function, Pregnancies, and Disease-Free Survival: A Randomized Clinical Trial
- Effect of Opioids vs NSAIDs and Larger vs Smaller Chest Tube Size on Pain Control and Pleurodesis Efficacy Among Patients With Malignant Pleural Effusion: The TIME1 Randomized Clinical Trial
- Ibrutinib as Initial Therapy for Patients with Chronic Lymphocytic Leukemia
Nutrition and blood
Musculoskeletal and joint diseases
- Secukinumab, an Interleukin-17A Inhibitor, in Ankylosing Spondylitis
- Effect of tight control of inflammation in early psoriatic arthritis (TICOPA): a UK multicentre, open-label, randomised controlled trial
Skin
Children
Cardiovascular system
Respiratory system
Central nervous system
Infections
Endocrine system
Obstetrics, gynaecology, and urinary-tract disorders
Malignant disease and immunosuppression
Eye
Skin
Immunological products and vaccines
Children
- Isosorbide Mononitrate in Heart Failure with Preserved Ejection Fraction
- Lixisenatide in Patients with Type 2 Diabetes and Acute Coronary Syndrome
- A Randomized Trial of Intensive versus Standard Blood-Pressure Control
- Effect of Vericiguat, a Soluble Guanylate Cyclase Stimulator, on Natriuretic Peptide Levels in Patients With Worsening Chronic Heart Failure and Reduced Ejection Fraction: The SOCRATES-REDUCED Randomized Trial
- Effect of Clopidogrel and Aspirin vs Aspirin Alone on Migraine Headaches After Transcatheter Atrial Septal Defect Closure: The CANOA Randomized Clinical Trial
- Effect of Intravascular Ultrasound–Guided vs Angiography-Guided Everolimus-Eluting Stent ImplantationThe IVUS-XPL Randomized Clinical Trial
- Spironolactone versus placebo, bisoprolol, and doxazosin to determine the optimal treatment for drug-resistant hypertension (PATHWAY-2): a randomised, double-blind, crossover trial
- Polymer-free Drug-Coated Coronary Stents in Patients at High Bleeding Risk
Respiratory system
Central nervous system
- Efficacy, safety, and tolerability of augmentation pharmacotherapy with aripiprazole for treatment-resistant depression in late life: a randomised, double-blind, placebocontrolled trial
- Comparative benefits and harms of second generation antidepressants and cognitive behavioral therapies in initial treatment of major depressive disorder: systematic review and meta-analysis
Infections
- On-Demand Preexposure Prophylaxis in Men at High Risk for HIV-1 Infection
- Acetaminophen for Fever in Critically Ill Patients with Suspected Infection
- Skin antisepsis with chlorhexidine–alcohol versus povidone iodine–alcohol, with and without skin scrubbing, for prevention of intravascular-catheter-related infection (CLEAN): an open-label, multicentre, randomised, controlled, two-by-two factorial trial
Endocrine system
- Association between use of warfarin with common sulfonylureas and serious hypoglycemic events: retrospective cohort analysis
- HbA1c overtesting and overtreatment among US adults with controlled type 2 diabetes, 2001-13: observational population based study
- Home Use of an Artificial Beta Cell in Type 1 Diabetes
- Empagliflozin, Cardiovascular Outcomes, and Mortality in Type 2 Diabetes
- Effect of Metformin Added to Insulin on Glycemic Control Among Overweight/Obese Adolescents With Type 1 Diabetes: A Randomized Clinical Trial
Obstetrics, gynaecology, and urinary-tract disorders
- A Randomized Trial of Progesterone in Women with Recurrent Miscarriages
- Long term trends in prevalence of neural tube defects in Europe: population based study
Malignant disease and immunosuppression
Eye
Skin
Immunological products and vaccines
- Immunogenicity of a new routine vaccination schedule for global poliomyelitis prevention: an open-label, randomised controlled trial
- Safety, efficacy, and immunogenicity of VGX-3100, a therapeutic synthetic DNA vaccine targeting human papillomavirus 16 and 18 E6 and E7 proteins for cervical intraepithelial neoplasia 2/3: a randomised, double-blind, placebo-controlled phase 2b trial
- Genetic Diversity and Protective Efficacy of the RTS,S/AS01 Malaria Vaccine
Children
Gastro-intestinal system
Cardiovascular system
Central nervous system
Endocrine system
Obstetrics, gynaecology and urinary tract disorders
Malignant disease and immunosuppression
Nutrition and blood
Musculoskeletal and joint diseases
Eye
Skin
Immunological products and vaccines
Children
Other
Cardiovascular system
- Prophylactic antibiotics after acute stroke for reducing pneumonia in patients with dysphagia (STROKE-INF): a prospective, cluster-randomised, open-label, masked endpoint, controlled clinical trial
- Effects of intensive blood pressure lowering on cardiovascular and renal outcomes: updated systematic review and meta-analysis
- Effect of the REG1 anticoagulation system versus bivalirudin on outcomes after percutaneous coronary intervention (REGULATE-PCI): a randomised clinical trial
- Randomized Trial of Benznidazole for Chronic Chagas’ Cardiomyopathy
- Antisense therapy targeting apolipoprotein(a): a randomised, double-blind, placebocontrolled phase 1 study
- Treatment strategies for coronary in-stent restenosis: systematic review and hierarchical Bayesian network meta-analysis of 24 randomised trials and 4880 patients
- Stroke and recurrent haemorrhage associated with antithrombotic treatment after gastrointestinal bleeding in patients with atrial fibrillation: nationwide cohort study
- Everolimus-Eluting Bioresorbable Scaffolds for Coronary Artery Disease
- Paclitaxel-Eluting versus Everolimus-Eluting Coronary Stents in Diabetes
Central nervous system
Endocrine system
- Epilepsy in pregnancy and reproductive outcomes: a systematic review and meta-analysis
- Liraglutide in people treated for type 2 diabetes with multiple daily insulin injections: randomised clinical trial (MDI Liraglutide trial)
Obstetrics, gynaecology and urinary tract disorders
- Effect of a Buffered Crystalloid Solution vs Saline on Acute Kidney Injury Among Patients in the Intensive Care UnitThe SPLIT Randomized Clinical Trial
- Grazoprevir plus elbasvir in treatment-naive and treatment-experienced patients with hepatitis C virus genotype 1 infection and stage 4–5 chronic kidney disease (the C-SURFER study): a combination phase 3 study
Malignant disease and immunosuppression
- Aromatase inhibitors versus tamoxifen in early breast cancer: patient-level meta-analysis of the randomised trials
- Adjuvant bisphosphonate treatment in early breast cancer: meta-analyses of individual patient data from randomised trials
- A Trial of Calcium and Vitamin D for the Prevention of Colorectal Adenomas
- DNA-Repair Defects and Olaparib in Metastatic Prostate Cancer
- Targeting Mutant BRAF in Relapsed or Refractory Hairy-Cell Leukemia
- Nivolumab versus Everolimus in Advanced Renal-Cell Carcinoma
- Cabozantinib versus Everolimus in Advanced Renal-Cell Carcinoma
- Pediatric Outcome after Maternal Cancer Diagnosed during Pregnancy
- Lenalidomide plus Rituximab as Initial Treatment for Mantle-Cell Lymphoma
Nutrition and blood
Musculoskeletal and joint diseases
- Calcium intake and bone mineral density: systematic review and meta-analysis
- Calcium intake and risk of fracture: systematic review
- Secukinumab Inhibition of Interleukin-17A in Patients with Psoriatic Arthritis
- Naproxen With Cyclobenzaprine, Oxycodone/Acetaminophen, or Placebo for Treating Acute Low Back Pain: A Randomized Clinical Trial
- The risk of fall and fracture with the initiation of a prostate-selective α antagonist: a population based cohort study
Eye
Skin
Immunological products and vaccines
- Public health impact and cost-effectiveness of the RTS,S/AS01 malaria vaccine: a systematic comparison of predictions from four mathematical models
- Feasibility and effectiveness of oral cholera vaccine in an urban endemic setting in Bangladesh: a cluster randomised open-label trial
- Association Between Hospitalization With Community-Acquired Laboratory Confirmed Influenza Pneumonia and Prior Receipt of Influenza Vaccination
- Efficacy, safety, and immunogenicity of an oral recombinant Helicobacter pylori vaccine in children in China: a randomised, double-blind, placebo-controlled, phase 3 trial
- Association of Tdap Vaccination With Acute Events and Adverse Birth Outcomes Among Pregnant Women With Prior Tetanus-Containing Immunizations
- Maternal vaccination against H1N1 influenza and offspring mortality: population based cohort study and sibling design
Children
- Eltrombopag for children with chronic immune thrombocytopenia (PETIT2): a randomised, multicentre, placebo-controlled trial
- Neurodevelopmental outcome at 2 years of age after general anaesthesia and awake-regional anaesthesia in infancy (GAS): an international multicentre, randomised controlled trial
- Early Inhaled Budesonide for the Prevention of Bronchopulmonary Dysplasia
- Early Administration of Azithromycin and Prevention of Severe Lower Respiratory Tract Illnesses in Preschool Children With a History of Such Illnesses: A Randomized Clinical Trial
- Efficacy and safety of cyclic pyranopterin monophosphate substitution in severe molybdenum cofactor deficiency type A: a prospective cohort study
Other