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The monthly TRFT Medicines Management Bulletin brings together the latest pharmacological research, organised by BNF category.  Contact us to subscribe and receive each issue by email. 

​November 2015

December 2015
January 2016

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Cardiovascular system
  • Ranolazine in patients with incomplete revascularisation after percutaneous coronary intervention (RIVER-PCI): a multicentre, randomised, double-blind, placebo-controlled trial
  • Safety and performance of the second-generation drug-eluting absorbable metal scaffold in patients with de-novo coronary artery lesions (BIOSOLVE-II): 6 month results of a prospective, multicentre, non-randomised, first-in-man trial
  • Availability and affordability of cardiovascular disease medicines and their effect on use in high-income, middle-income, and low-income countries: an analysis of the PURE study data
  • Selexipag for the Treatment of Pulmonary Arterial Hypertension

Central nervous system
  • Erythropoietin in traumatic brain injury (EPO-TBI): a double-blind randomised controlled trial

Infections
  • Effect of Artesunate–Amodiaquine on Mortality Related to Ebola Virus Disease
  • Pre-exposure prophylaxis to prevent the acquisition of HIV-1 infection (PROUD): effectiveness results from the pilot phase of a pragmatic open-label randomised trial
  • Azithromycin versus Doxycycline for Urogenital Chlamydia trachomatis Infection
  • Sofosbuvir and Velpatasvir for HCV Genotype 1, 2, 4, 5, and 6 Infection
  • Sofosbuvir and Velpatasvir for HCV Genotype 2 and 3 Infection
  • Sofosbuvir and Velpatasvir for HCV in Patients with Decompensated Cirrhosis
  • Intermittent screening and treatment or intermittent preventive treatment with dihydroartemisinin–piperaquine versus intermittent preventive treatment with sulfadoxine–pyrimethamine for the control of malaria during pregnancy in western Kenya: an open-label, three-group, randomised controlled superiority trial

Obstetrics, gynaecology, and urinary-tract disorders
  • Maternal use of oral contraceptives and risk of birth defects in Denmark: Prospective, nationwide cohort study
  • Ibuprofen versus fosfomycin for uncomplicated urinary tract infection in women: Randomised controlled trial
  • Association Between Use of Oral Fluconazole During Pregnancy and Risk of Spontaneous Abortion and Stillbirth

Malignant disease and immunosuppression
  • Antilymphocyte Globulin for Prevention of Chronic Graft-versus-Host Disease
  • Resensitization to Crizotinib by the Lorlatinib ALK Resistance Mutation L1198F
  • Second Cancer Risk Up to 40 Years after Treatment for Hodgkin’s Lymphoma
  • Ovarian Suppression With Triptorelin During Adjuvant Breast Cancer Chemotherapy and Long-term Ovarian Function, Pregnancies, and Disease-Free Survival: A Randomized Clinical Trial
  • Effect of Opioids vs NSAIDs and Larger vs Smaller Chest Tube Size on Pain Control and Pleurodesis Efficacy Among Patients With Malignant Pleural Effusion: The TIME1 Randomized Clinical Trial
  • Ibrutinib as Initial Therapy for Patients with Chronic Lymphocytic Leukemia

Nutrition and blood
  • Andexanet Alfa for the Reversal of Factor Xa Inhibitor Activity

Musculoskeletal and joint diseases
  • Secukinumab, an Interleukin-17A Inhibitor, in Ankylosing Spondylitis
  • Effect of tight control of inflammation in early psoriatic arthritis (TICOPA): a UK multicentre, open-label, randomised controlled trial

Skin
  • Efficacy and safety of dupilumab in adults with moderate-to-severe atopic dermatitis inadequately controlled by topical treatments: a randomised, placebo-controlled, dose-ranging phase 2b trial

Children
  • Current concepts in management of pain in children in the emergency department

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Cardiovascular system
  • Isosorbide Mononitrate in Heart Failure with Preserved Ejection Fraction
  • Lixisenatide in Patients with Type 2 Diabetes and Acute Coronary Syndrome
  • A Randomized Trial of Intensive versus Standard Blood-Pressure Control
  • Effect of Vericiguat, a Soluble Guanylate Cyclase Stimulator, on Natriuretic Peptide Levels in Patients With Worsening Chronic Heart Failure and Reduced Ejection Fraction: The SOCRATES-REDUCED Randomized Trial
  • Effect of Clopidogrel and Aspirin vs Aspirin Alone on Migraine Headaches After Transcatheter Atrial Septal Defect Closure: The CANOA Randomized Clinical Trial
  • Effect of Intravascular Ultrasound–Guided vs Angiography-Guided Everolimus-Eluting Stent ImplantationThe IVUS-XPL Randomized Clinical Trial
  • Spironolactone versus placebo, bisoprolol, and doxazosin to determine the optimal treatment for drug-resistant hypertension (PATHWAY-2): a randomised, double-blind, crossover trial
  • Polymer-free Drug-Coated Coronary Stents in Patients at High Bleeding Risk

Respiratory system
  • Activity of Oral ALS-008176 in a Respiratory Syncytial Virus Challenge Study

Central nervous system
  • Efficacy, safety, and tolerability of augmentation pharmacotherapy with aripiprazole for treatment-resistant depression in late life: a randomised, double-blind, placebocontrolled trial
  • Comparative benefits and harms of second generation antidepressants and cognitive behavioral therapies in initial treatment of major depressive disorder: systematic review and meta-analysis

Infections
  • On-Demand Preexposure Prophylaxis in Men at High Risk for HIV-1 Infection
  • Acetaminophen for Fever in Critically Ill Patients with Suspected Infection
  • Skin antisepsis with chlorhexidine–alcohol versus povidone iodine–alcohol, with and without skin scrubbing, for prevention of intravascular-catheter-related infection (CLEAN): an open-label, multicentre, randomised, controlled, two-by-two factorial trial

Endocrine system
  • Association between use of warfarin with common sulfonylureas and serious hypoglycemic events: retrospective cohort analysis
  • HbA1c overtesting and overtreatment among US adults with controlled type 2 diabetes, 2001-13: observational population based study
  • Home Use of an Artificial Beta Cell in Type 1 Diabetes
  • Empagliflozin, Cardiovascular Outcomes, and Mortality in Type 2 Diabetes
  • Effect of Metformin Added to Insulin on Glycemic Control Among Overweight/Obese Adolescents With Type 1 Diabetes: A Randomized Clinical Trial

Obstetrics, gynaecology, and urinary-tract disorders
  • A Randomized Trial of Progesterone in Women with Recurrent Miscarriages
  • Long term trends in prevalence of neural tube defects in Europe: population based study

Malignant disease and immunosuppression
  • Intensive Supportive Care plus Immunosuppression in IgA Nephropathy

​Eye
  • Panretinal Photocoagulation vs Intravitreous Ranibizumab for Proliferative Diabetic Retinopathy

Skin
  • Mass Drug Administration for Scabies Control in a Population with Endemic Disease

Immunological products and vaccines
  • Immunogenicity of a new routine vaccination schedule for global poliomyelitis prevention: an open-label, randomised controlled trial
  • Safety, efficacy, and immunogenicity of VGX-3100, a therapeutic synthetic DNA vaccine targeting human papillomavirus 16 and 18 E6 and E7 proteins for cervical intraepithelial neoplasia 2/3: a randomised, double-blind, placebo-controlled phase 2b trial
  • Genetic Diversity and Protective Efficacy of the RTS,S/AS01 Malaria Vaccine

Children
  • Methylphenidate for attention-deficit/hyperactivity disorder in children and adolescents: Cochrane systematic review with meta-analyses and trial sequential analyses of randomised clinical trials

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Gastro-intestinal system
  • Early combined immunosuppression for the management of Crohn's disease (REACT): a cluster randomised controlled trial

Cardiovascular system
  • Prophylactic antibiotics after acute stroke for reducing pneumonia in patients with dysphagia (STROKE-INF): a prospective, cluster-randomised, open-label, masked endpoint, controlled clinical trial
  • Effects of intensive blood pressure lowering on cardiovascular and renal outcomes: updated systematic review and meta-analysis
  • Effect of the REG1 anticoagulation system versus bivalirudin on outcomes after percutaneous coronary intervention (REGULATE-PCI): a randomised clinical trial
  • Randomized Trial of Benznidazole for Chronic Chagas’ Cardiomyopathy
  • Antisense therapy targeting apolipoprotein(a): a randomised, double-blind, placebocontrolled phase 1 study
  • Treatment strategies for coronary in-stent restenosis: systematic review and hierarchical Bayesian network meta-analysis of 24 randomised trials and 4880 patients
  • Stroke and recurrent haemorrhage associated with antithrombotic treatment after gastrointestinal bleeding in patients with atrial fibrillation: nationwide cohort study
  • Everolimus-Eluting Bioresorbable Scaffolds for Coronary Artery Disease
  • Paclitaxel-Eluting versus Everolimus-Eluting Coronary Stents in Diabetes

Respiratory system
  • Anticholinergic vs Long-Acting β-Agonist in Combination With Inhaled  Corticosteroids in Black Adults With Asthma: The BELT Randomized Clinical Trial

Central nervous system
  • Daclizumab HYP versus Interferon Beta-1a in Relapsing Multiple Sclerosis

​Endocrine system
  • Epilepsy in pregnancy and reproductive outcomes: a systematic review and meta-analysis
  • Liraglutide in people treated for type 2 diabetes with multiple daily insulin injections: randomised clinical trial (MDI Liraglutide trial)

Obstetrics, gynaecology and urinary tract disorders
  • Effect of a Buffered Crystalloid Solution vs Saline on Acute Kidney Injury Among  Patients in the Intensive Care UnitThe SPLIT Randomized Clinical Trial
  • Grazoprevir plus elbasvir in treatment-naive and treatment-experienced patients with hepatitis C virus genotype 1 infection and stage 4–5 chronic kidney disease (the C-SURFER study): a combination phase 3 study

Malignant disease and immunosuppression
  • Aromatase inhibitors versus tamoxifen in early breast cancer: patient-level meta-analysis of the randomised trials
  • Adjuvant bisphosphonate treatment in early breast cancer: meta-analyses of individual patient data from randomised trials
  • A Trial of Calcium and Vitamin D for the Prevention of Colorectal Adenomas
  • DNA-Repair Defects and Olaparib in Metastatic Prostate Cancer
  • Targeting Mutant BRAF in Relapsed or Refractory Hairy-Cell Leukemia
  • Nivolumab versus Everolimus in Advanced Renal-Cell Carcinoma
  • Cabozantinib versus Everolimus in Advanced Renal-Cell Carcinoma
  • Pediatric Outcome after Maternal Cancer Diagnosed during Pregnancy
  • Lenalidomide plus Rituximab as Initial Treatment for Mantle-Cell Lymphoma

Nutrition and blood
  • Comparative Risk of Anaphylactic Reactions Associated With Intravenous Iron Products

Musculoskeletal and joint diseases
  • Calcium intake and bone mineral density: systematic review and meta-analysis
  • Calcium intake and risk of fracture: systematic review
  • Secukinumab Inhibition of Interleukin-17A in Patients with Psoriatic Arthritis
  • Naproxen With Cyclobenzaprine, Oxycodone/Acetaminophen, or Placebo for Treating Acute Low Back Pain: A Randomized Clinical Trial
  • The risk of fall and fracture with the initiation of a prostate-selective α antagonist: a population based cohort study

Eye
  • Tasimelteon for non-24-hour sleep–wake disorder in totally blind people (SET and RESET): two multicentre, randomised, double-masked, placebo-controlled phase 3 trials

Skin
  • Phase 3 Studies Comparing Brodalumab with Ustekinumab in Psoriasis

Immunological products and vaccines
  • Public health impact and cost-effectiveness of the RTS,S/AS01 malaria vaccine: a systematic comparison of predictions from four mathematical models
  • Feasibility and effectiveness of oral cholera vaccine in an urban endemic setting in Bangladesh: a cluster randomised open-label trial
  • Association Between Hospitalization With Community-Acquired Laboratory Confirmed Influenza Pneumonia and Prior Receipt of Influenza Vaccination
  • Efficacy, safety, and immunogenicity of an oral recombinant Helicobacter pylori vaccine in children in China: a randomised, double-blind, placebo-controlled, phase 3 trial
  • Association of Tdap Vaccination With Acute Events and Adverse Birth Outcomes Among Pregnant Women With Prior Tetanus-Containing Immunizations
  • Maternal vaccination against H1N1 influenza and offspring mortality: population based cohort study and sibling design

Children
  • Eltrombopag for children with chronic immune thrombocytopenia (PETIT2): a randomised, multicentre, placebo-controlled trial
  • Neurodevelopmental outcome at 2 years of age after general anaesthesia and awake-regional anaesthesia in infancy (GAS): an international multicentre, randomised controlled trial
  • Early Inhaled Budesonide for the Prevention of Bronchopulmonary Dysplasia
  • Early Administration of Azithromycin and Prevention of Severe Lower Respiratory Tract Illnesses in Preschool Children With a History of Such Illnesses: A Randomized Clinical Trial
  • Efficacy and safety of cyclic pyranopterin monophosphate substitution in severe molybdenum cofactor deficiency type A: a prospective cohort study

​Other
  • Association between guideline recommended drugs and death in older adults with multiple chronic conditions: population based cohort study
  • Examining variations in prescribing safety in UK general practice: cross sectional study using the Clinical Practice Research Datalink
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